The San Francisco 49ers have made a flying start to the NFL season with four straight wins, but we’re backing the Seattle Seahawks to burst their bubble this weekend. After beating an undercooked Los Angeles Rams outfit in Melbourne , the 49ers have made the most of home advantage for the last three Sundays.
Visiting Lumen Field will provide them with a much different test, though, and we like 11/10 for the hosts to lead at half-time and full-time for our first Seattle Seahawks vs San Francisco 49ers prediction.
Betting Odds
Seattle Seahawks vs San Francisco 49ers Betting Odds – NFL 2026-27
Result | Odds | Chance |
|---|---|---|
Seahawks | 8/13 | 61.9% |
49ers | 13/10 | 43.5% |
*Odds are correct at the time of writing, but subject to change.
The Seahawks are 8/13 favourites to beat the 49ers , who are 13/10 to win.
How to Watch
How to watch Seattle Seahawks vs San Francisco 49ers
Sunday’s mouth-watering match-up is scheduled to kick off at 21:25 BST and will be broadcast live on Sky Sports Main Event.
Head-to-Head
Seattle Seahawks vs San Francisco 49ers head-to-head record
Honours were even between these teams during the regular season last term, but the Seahawks then dominated from start to finish when romping to a 41-6 victory in Seattle during the play-offs.
Early Payout Offer
17 Points Ahead Early Payout
Back your NFL team with BOYLE Sports today. If they build a 17-point lead at any stage of the game, your bet is paid out as a winner right away, regardless of the final score. T&Cs apply.
Form Guides
Seattle Seahawks form guide
The Seahawks seem to have suffered a bit of a hangover from last season’s superb Super Bowl success and the subsequent departure of running back Kenneth Walker III but are still well placed at 3-1. Seattle left it late before beating the New England Patriots 13-10 first up and again did their better work in the second half of an ultimately comfortable 31-7 triumph at the Arizona Cardinals.
A 12-game winning streak came to a surprise end when they went down 33-31 away to the Washington Commanders but at least that shock defeat served as a wake-up call, judged on last week’s 30-23 victory over the Los Angeles Chargers at this venue. For the first time this term, Seattle were fired up from the outset, powering into a 20-6 half-time lead and extending their advantage to 30-13 before a late rally flattered the Chargers .
Strangely enough, star wide receiver Jaxon Smith-Njigba had his quietest game of the campaign so far in that contest, albeit still leading the way with five receptions for 76 yards. The 24-year-old reigning NFL Offensive Player of the Year had previously racked up tallies of 122, 155 and 128, so 5/6 for him to have over 91.5 receiving yards here stands out from the Seattle Seahawks vs San Francisco 49ers odds.
San Francisco 49ers form guide
The 49ers made an early statement of intent with their 27-7 mauling of the Rams at the MCG and then breezed past the Miami Dolphins 35-13 before being made to work much harder for a 36-30 win over the Arizona Cardinals.
Last Sunday’s clash with the Denver Broncos was a real arm-wrestle for almost three quarters, but San Francisco held their nerve and came home strong to secure a 24-14 success against rock-solid opponents. The big guns have all been firing, with quarterback Brock Purdy , running back Christian McCaffrey, wide receiver Deebo Samuel and tight end George Kittle each doing their bit.
However, the 49ers have been battling through some serious injury issues on defence and we just fear this tough first genuine away game could be when they really feel the effects of several key absences. Let’s add 2/1 for Seattle to win and over 45.5 total points to our Seahawks vs 49ers betting tips.
Betting Tips
Seattle Seahawks vs San Francisco 49ers Betting Tips - NFL 2026-27
Jaxon Smith-Njigba over 91.5 receiving yards @ 5/6
Seattle to win and over 45.5 total points @ 2/1
Simply click/tap on the above betting tips to add to your betslip.
Bet on NFL Odds at BOYLE Sports
*Prices are subject to fluctuation
Remember, Always Gamble Responsibly
Not all opinions are equal. The BOYLE Sports Team is made up of experts who know the sports and betting world inside out, delivering the kind of insights and analysis that give you a real edge where it matters most.
