NFL Week 3 predictions & betting tips: Giants, 49ers & Rams feature in 5/1 treble

American Football
BOYLE Sports Team · Betting Experts

With the new NFL season already more than a fortnight old, teams will be looking to settle down and start showing their true worth.

Here, we have selected three NFL Week 3 betting tips that will give us a 5/1-plus treble if they all come up trumps:

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Giants vs Titans

NEW YORK GIANTS -2.5 POINTS TO BEAT TENNESSEE TITANS @ 4/5

The Giants can be forgiven for reacting badly to Jaxson Dart suffering a season-ending knee injury on the opening drive of last week’s 28-6 loss to the Rams and the hope is that veteran back-up quarterback Jameis Winston will be a different proposition with time to prepare.

Some of the excitement generated by a previous 28-20 triumph over the Dallas Cowboys in John Harbaugh’s debut as head coach may have evaporated, but this remains a promising roster that is well placed to improve greatly on a 2025 record of 4-13.

Hosting the Titans is a golden opportunity to justify that faith, with Tennessee coming off a couple of 3-14 campaigns and already on course to struggle again this term after two home defeats, albeit they did perform with some credit against Philadelphia last Sunday.

4/5
● LIVE ODDS New York Giants Handicap Betting

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49s vs Cardinals

SAN FRANCISCO 49ERS -8.5 POINTS TO BEAT ARIZONA CARDINALS @ 10/11

All of the early signs are positive for San Francisco , who followed up a notable 27-7 triumph over the LA Rams in Australia by brushing aside the Miami Dolphins 35-13 in front of their own fans.

Quarterback Brock Purdy really does have some powerful weapons at his disposal in the passing game, with Mike Evans settling in well after being added to an already strong air attack which includes George Kittle , Deebo Samuel and the underrated Demarcus Robinson .

Christian McCaffrey is always hungry for rushing touchdowns and the 49ers are fancied to simply overwhelm the Cardinals , who upset the LA Chargers in Week 1 but soon had their bubble burst via a 31-7 thrashing by Seattle in Arizona .

10/11
● LIVE ODDS San Francisco 49ers Handicap Betting

Broncos vs Rams

LOS ANGELES RAMS -2.5 POINTS TO WIN AT DENVER BRONCOS @ 5/6

Denver bounced back from a mauling at Kansas City to beat Jacksonville 20-13 on home turf, getting going just in time to overcome another slow start, but the Broncos will have to step up to a much higher level to match this weekend’s opponents.

The Rams put a poor Melbourne performance against San Francisco firmly behind them by routing the New York Giants in Los Angeles to re-establish themselves as favourites for Super Bowl glory this season.

Losing major off-season signing Myles Garrett to injury is a setback on defence, but Sean McVay’s much-vaunted offence found a nice rhythm against the Giants in all departments and could be boosted even further by the return of wide receiver Puka Nacua.

5/6
● LIVE ODDS Los Angeles Rams Handicap Betting

NFL Acca

NFL Acca

Giants -2.5 points to beat Titans @ 4/5

49ers -8.5 points to beat Cardinals @ 10/11

Rams -2.5 points to win at Broncos @ 5/6

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BOYLE Sports Team · Betting Experts

Not all opinions are equal. The BOYLE Sports Team is made up of experts who know the sports and betting world inside out, delivering the kind of insights and analysis that give you a real edge where it matters most.

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