The Buffalo Bills have quickly cemented their position as one of the favourites for Super Bowl LXI glory and should be capable of brushing aside perennial strugglers the Las Vegas Raiders on the road.
Kicking off the campaign with a hat-trick of wins before pushing the Kansas City Chiefs close had Raiders fans dreaming of a resurgence, but last week’s 45-17 drubbing by the New England Patriots suggests that may have been yet another false dawn.
Given the manner of that defeat, we’re happy to back the visitors to win by more than 4.5 points – Bills -4.5 points @ 20/23 – as our initial Las Vegas Raiders vs Buffalo Bills prediction.
Betting Odds
Las Vegas Raiders vs Buffalo Bills Betting Odds – NFL 2026/27
Result | Odds | Chance |
|---|---|---|
Raiders | 2/1 | 33.3% |
Bills | 2/5 | 71.4% |
*Odds are correct at the time of writing, but subject to change.
The Bills are 2/5 favourites to beat the Raiders, who are 2/1 to win.
How to Watch
How to Watch Las Vegas Raiders vs Buffalo Bills
Las Vegas Raiders vs Buffalo Bills kicks off at 9:25pm (UK and Irish time) on Sunday 18 October at Allegiant Stadium, live on Sky Sports Main Event and Channel 5.
Head-to-Head
Las Vegas Raiders vs Buffalo Bills Head-to-Head Record
Buffalo made it three straight wins over the Raiders when romping to a 38-10 home victory in their last meeting back in September 2023.
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Form Guides
Las Vegas Raiders Form Guide
Veteran quarterback Kirk Cousins was brought in to give number one draft pick Fernando Mendoza time to settle, and he did that job well across the first four games.
Admittedly, the Raiders were handed a kind early schedule which brought wins over the Miami Dolphins, the Los Angeles Chargers and the New Orleans Saints, and a narrow 30-27 defeat to the Chiefs was a creditable display.
However, all of that good work went out of the window as Las Vegas put in a lacklustre showing away to New England, which allowed the previously struggling Patriots to rack up over 500 yards on offence and score points at will.
The Raiders’ last three games have now produced 181 points – an average of just over 60 a game – and it is hard to see how they are going to stop Buffalo’s wide array of attacking talent. Looking at the Raiders vs Bills odds, Bills to win & over 53.5 points @ 8/5 has obvious appeal.
Buffalo Bills Form Guide
The Bills improved their record to 4-1 when shading the much-vaunted Los Angeles Rams 37-34 after overtime on a wild Monday night at SoFi Stadium. Turnovers played a big part in that frantic contest for both teams and Buffalo’s star running back James Cook continued to have problems holding on to the ball.
However, Cook did still get into the end zone for two touchdowns and quarterback Josh Allen once again showed why he is rated among the best in the business with another dazzling display. Only one of Buffalo’s five matches this term has produced fewer than 55 points, backing up our earlier selection, and a big part of that is down to the dual threat of Allen.
The 30-year-old was down on passing yards against the Rams with just 210, but made up for that by adding 121 on the ground, meaning he is currently averaging 297.6 total yards per game. With Allen playing indoors against a shellshocked defence, over 280.5 passing and rushing yards @ 5/6 is hard to resist for our Las Vegas Raiders vs Buffalo Bills betting tips.
Betting Tips
Las Vegas Raiders vs Buffalo Bills Betting Tips – NFL 2026/27
Bills -4.5 points to win @ 20/23
Bills to win & over 53.5 points @ 8/5
Josh Allen over 280.5 passing and rushing yards @ 5/6
Simply click/tap on the above betting tips to add to your betslip.
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*Prices are subject to fluctuation.
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