The Los Angeles Chargers could not have made a worse start to the new NFL season and it is hard to see them bouncing back when visiting the Buffalo Bills . Opening with home games against the Arizona Cardinals and the Las Vegas Raiders should have set the Chargers up for a flyer, with both of those opponents coming off 3-14 campaigns in 2025.
However, things have gone horribly wrong for Jim Harbaugh ’s side, losing each match by 12 points , and now they must face a red-hot Bills outfit on the road. We’re snapping up 1/8 for a home win by more than 6.5 points from the list of alternative handicap options for our initial Buffalo Bills vs Los Angeles Chargers prediction.
How to Watch
How to watch Buffalo Bills vs Los Angeles Chargers
Sunday’s clash is scheduled to kick off at 18:00 BST and will be broadcast live on Sky Sports Main Event .
Head-to-Head
Buffalo Bills vs Los Angeles Chargers head-to-head record
These teams are infrequent rivals, but the Bills have won the last two encounters , prevailing 27-17 at home in 2020 and 24-22 in LA just under three years ago.
Form Guides
Buffalo Bills form guide
Buffalo’s five-year reign as AFC East champions may have come to an end last season, but they still finished with a fine 12-5 record and beat the Jacksonville Jaguars in the Wild Card round before only losing in overtime away to the Denver Broncos . A consistent run of regular-season success followed by play-offs heartbreak wasn’t enough to save head coach Sean McDermott , though, as he was axed after a decade in charge.
However, promoting offensive coordinator Joe Brady to the top job has so far looked an inspired decision , with the Bills building on a trio of pre-season victories by winning 36-31 away to the Houston Texans and then defeating the Detroit Lions 41-31 at their new home ground. Superstar quarterback Josh Allen lit up the impressive Highmark Stadium by throwing three touchdown passes and rushing for two more scores , with the 30-year-old looking better than ever.
James Cook is right up there with the best running backs , trading for DJ Moore has elevated the wide receiver core and tight end Dalton Kincaid has followed up a first Pro Bowl selection with a strong start. Despite the outstanding early form of linebacker Greg Rousseau , there is clearly still some work to do on defence, but 6/4 for a home win and over 50.5 total points is a tempting option from the Buffalo Bills vs Los Angeles Chargers odds.
Los Angeles Chargers form guide
The Chargers had been very consistent since bringing in Harbaugh as head coach, registering rock-solid 11-6 records in each of the past two seasons , before fluffing their lines in the play-offs. It was hoped that bringing in former Miami Dolphins supremo Mike McDaniel as offensive coordinator would give them more spark in attack but that has been far from the case so far.
QB Justin Herbert has at times looked like a deer caught in the headlights as he tries to adapt to a new system behind a fragile offensive line, while dropped passes, fumbles and penalties haven’t helped. The defensive work has been less alarming but still lacking bite and going down 26-14 against both the Cardinals and the Raiders at SoFi Stadium is pretty much as bad as it gets.
Let’s add a Bet Builder of 9/2 for Buffalo to win and Cook to score the first touchdown to our Bills vs Chargers betting tips.
Betting Tips
Buffalo Bills vs Los Angeles Chargers Betting Tips
Buffalo Bills win by more than 6.5 points @ 1/8
Buffalo Bills to win and over 50.5 total points @ 6/4
Buffalo Bills to win and James Cook III to score first touchdown @ 9/2
*Prices subject to fluctuation
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