Napoli vs Chelsea prediction with expert betting tips and latest odds as the two sides meet in a decisive Champions League clash.
Chelsea occupy the eighth and final spot in the race for automatic qualification for the last 16, but they arguably look most at risk of dropping out in Wednesday's final round.
Aside from the match between sixth-placed PSG and seventh-placed Newcastle , all of the seven teams immediately around Chelsea appear, on paper, to have easier fixtures than the Londoners' trip to Napoli.
Napoli vs Chelsea Prediction - CL 2025/26
The Serie A champions may not be having the best of seasons, lying fourth domestically and 25th in the Champions League, but Naples is never an easy place for visiting clubs.
To illustrate that point, seven of Napoli’s eight points this campaign have come at the Stadio Diego Armando Maradona , while they have won eight of their previous 11 home matches against English opposition.
With former Chelsea boss Antonio Conte in the dugout and ex- Blues striker Romelu Lukaku finally back from injury, Napoli will be fired up to avoid a costly European elimination, and we think they will beat the Blues @ 2/1 , which is our opening Napoli vs Chelsea prediction.
Betting Odds
Napoli vs Chelsea Betting Odds – Champions League 2025/26
Result | Odds | Chance |
|---|---|---|
Napoli | 13/5 | 27.8% |
Chelsea | 20/21 | 51.2% |
Draw | 12/5 | 29.4% |
Odds are correct at the time of writing, but subject to change.
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Napoli vs Chelsea Preview
A high-stakes European night awaits at the Stadio Diego Armando Maradona , where Napoli must win to keep their Champions League hopes alive.
Chelsea arrive knowing even a draw could be enough, but their fragile position means there is little margin for error against a fired-up home side.
How to Watch
How to Watch Napoli vs Chelsea
The match is scheduled to begin at 8pm and will be shown live on TNT Sports 4.
Team Form Guides
Napoli Form Guide
Napoli’s grip on the title was further loosened with Sunday’s 3-0 loss at Juventus.
That left Conte’s men with just one win in their last five league matches and now nine points behind leaders Inter Milan.
The Partenopei also saw their European hopes suffer a damaging blow last Tuesday when they could only draw 1-1 at a Copenhagen side who were reduced to 10 men in the 35th minute.
Napoli are therefore heading out of the Champions League as things stand but will look to their impressive home record — unbeaten on home soil in 16 games this season — to come to their rescue.
They have also been boosted by the return of Lukaku, who made his first appearance of the season as a late substitute against Juventus.
Conte may not be willing to risk the Belgium international from the start but he could offer good value @ 13/8 to net at any time while Scott McTominay , who took his goal tally to 10 this season against Copenhagen , can be backed @ 5/2 from the Napoli vs Chelsea odds.
Chelsea Form Guide
Chelsea’s switch from Enzo Maresca to Liam Rosenior on the bench has been paying early dividends with the new boss having won four of his five matches in charge.
The Blues struggled to overcome Pafos at Stamford Bridge last Wednesday but were much more clinical in seeing off Crystal Palace 3-1 on Sunday to move up to fifth in the Premier League.
Enzo Fernandez scored his ninth goal of the season against Palace and, with four of those coming since Christmas, the World Cup-winner might be worth backing against Napoli.
The Argentina midfielder, who is Chelsea’s penalty-taker, is 11/4 to score on Wednesday while Joao Pedro is 15/8 and looks to have the scoring touch after netting in successive Premier League matches, and that completes our Napoli vs Chelsea betting tips.
Betting Tips
Napoli vs Chelsea Betting Tips
Napoli to win @ 2/1
Romelu Lukaku to score anytime @ 13/8
Scott McTominay to score anytime @ 5/2
Simply click/tap on the above betting tips to add to your betslip.
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